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down-at-heel
down-bow
down climbing
Down East
Down Low
down payment
down quark
Down’s syndrome
Down syndrome
down-the-line
down-to-earth
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Down syndrome

Down syn·drome [ dówn sìn drm ] or Down's syn·drome [ dównz sìn drm ]


noun 
Definition:
 
genetic disorder: a genetic disorder characterized by a broad skull, blunt facial features, short stature, and learning difficulties. It is caused by the presence of an extra copy of a specific chromosome.

[Mid-20th century. After J. H. L. Down (1828-1896), English physician]
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