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Therefore and thus are both fairly formal words that introduce a statement that is a consequence of the previous statement. They should not be used as empty connectors when what follows them does not derive from what precedes them: Your grade on the test was 20 percent; therefore, you have failed. It is tautologous to use so therefore: just therefore is sufficient. Punctuation around therefore requires some care. There is no comma between clauses where therefore is in the second clause, but instead a semicolon or a new sentence: I had forgotten my key; therefore, I could not open the door.She left the library at 4 o'clock. She was therefore not there when the murder took place.
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